Healthier living could reduce worldwide dementia by one-third – Alzheimer’s – Optimum Senior Care – Chicago In Home Caregivers

Healthier living could reduce worldwide dementia by one-third – Alzheimer’s – Optimum Senior Care – Chicago In Home Caregiverswww.OptimumSeniorCare.com

Up to one-third of dementia cases worldwide could be prevented by addressing factors such as education, hypertension, diet, hearing loss and depression over the course of a person’s lifetime, according to a new report presented at last week’s Alzheimer’s Association International Conference® 2017 in London. Compiled by the first Lancet Commission on Dementia Prevention and Care, the report identifies nine risk factors over a person’s life span. Researchers considered each factor separately and how they related to one another to calculate how much modification of each may affect a person’s dementia risk.

Traveling with dementia – Alzheimer’s – Optimum Senior Care – Chicago In Home Caregivers

Traveling with dementia – Alzheimer’s – Optimum Senior Care – Chicago In Home Caregiverswww.OptimumSeniorCare.com

Summer is a busy travel season for many, this includes those with Alzheimer’s. People diagnosed with Alzheimer’s can still travel, though it may require extra planning to ensure safety and enjoyment for everyone. Whether taking a short trip to see friends and family or traveling a far distance for vacation, it’s important to consider the difficulties and benefits of travel for a person with dementia.

If a person has Alzheimer’s or other dementia, it doesn’t mean he or she can no longer participate in meaningful activities such as travel; but it does require planning to ensure safety and enjoyment for everyone.

Deciding to travel

Whether taking a short trip to see friends and family or traveling a far distance for vacation, it’s important to consider the difficulties and benefits of travel for a person with dementia. In the early stages of dementia, a person may still enjoy traveling. As the disease progresses, travel may become too overwhelming.

When you take into account the needs, abilities, safety and preferences of the person with dementia, what’s the best mode of travel? Consider the following:

  • Go with the option that provides the most comfort and the least anxiety.
  • Stick with the familiar. Travel to known destinations that involve as few changes in daily routine as possible. Try to visit places that were familiar before the onset of dementia.
  • Keep in mind that there may come a time when traveling is too disorienting or stressful for the person with dementia.
Tips for a safe trip
  • Changes in environment can trigger wandering. Even for a person in the early stages, new environments may be more difficult to navigate. Keep the person safe by taking precautions, such as enrolling in MedicAlert® + Alzheimer’s Association Safe Return®.

    If you will be at a location for an extended period of time, consider contacting the local Alzheimer’s Association for resources and support.
    Find a chapter anywhere in the United States.

  • Have a bag of essentials with you at all times that includes medications, your travel itinerary, a comfortable change of clothes, water, snacks and activities.
  • Pack necessary medications, up-to-date medical information, a list of emergency contacts and photocopies of important legal documents.
  • Create an itinerary that includes details about each destination. Give copies to emergency contacts at home. Keep a copy of your itinerary with you at all times.
  • If you will be staying in a hotel, inform the staff ahead of time of your specific needs so they can be prepared to assist you.
  • Travel during the time of day that is best for the person with dementia.

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Documents to Take with You when Traveling

  • Doctors’ names and contact information
  • A list of current medications and dosages
  • Phone numbers and addresses of the local police and fire departments, hospitals and poison control
  • A list of food or drug allergies
  • Copies of legal papers (living will, advanced directives, power of attorney, etc.)
  • Names and contact information of friends and family members to call in case of an emergency
  • Insurance information (policy number, member name)
Air travel

From our Blog

The Love Story of a Football Wife Who Tackled Dementia
Sylvia Mackey was a caregiver for husband and football legend John Mackey, who had dementia. Here, she tells her story and details the obstacles she faced and overcame when traveling to the Super Bowl each year. Read more

Traveling in airports requires plenty of focus and attention. At times, the level of activity can be distracting, overwhelming or difficult to understand for someone with dementia. If you are traveling by plane, keep the following in mind:

  • Avoid scheduling flights that require tight connections. Ask about airport escort services that can help you get from place to place.
  • Even if walking is not difficult, consider requesting a wheelchair so that an attendant can help you get from place to place. Most airlines ask for at least 48 hours notice.
  • Contact the Transportation Security Administration (TSA) at least 72 hours prior to travel for information about what to expect during the security screening. While at the airport, remind the person what is involved and consider telling the agent at the security checkpoint that the person has dementia.
  • Do not hesitate to ask for assistance from airport employees and in-flight crew.
  • If the person needs help using the restroom, look for companion care bathrooms so you can more easily assist and will not have to leave the person unattended.
  • Stay with the person at all times

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Alzheimer’s Association announces new study to test impact of lifestyle on preventing cognitive decline – Optimum Senior Care – Chicago In Home Caregivers

Alzheimer’s Association announces new study to test impact of lifestyle on preventing cognitive decline – Optimum Senior Care – Chicago In Home Caregiverswww.OptimumSeniorCare.com

At AAIC 2017, the Alzheimer’s Association announced the launch of the U.S. study to PrOtect through a lifestyle INTErvention to Reduce risk (US POINTER), a $20 million, two-year clinical trial to test the ability of a multidimensional lifestyle intervention to prevent cognitive decline and dementia. The study will include physical exercise, nutritional counseling and modification, cognitive and social stimulation, and improved self-management of medical conditions. Recruiting for the study will begin in 2018.

– Results from 4,000 Participants re: Impact of Brain Amyloid Imaging on Medical Management –

– Possible Blood Test for Amyloid –

LONDON, July 19, 2017 — The Alzheimer’s Association today announced the launch of a $20 million U.S. two- year clinical trial to test the ability of a multi-dimensional lifestyle intervention to prevent cognitive decline and dementia in 2,500 older adults with no current cognitive symptoms but who are at increased risk for later cognitive decline. The announcement was made at the 2017 Alzheimer’s Association International Conference (AAIC 2017) in London.

The large U.S. study to PrOtect through a lifestyle INTErvention to Reduce risk (US POINTER) will include physical exercise, nutritional counseling and modification, cognitive and social stimulation, and improved self- management of medical conditions. Recruiting for the study will begin in 2018.

At AAIC 2014, Miia Kivipelto, M.D., Ph.D., Professor at the Karolinska Institutet, Sweden and the National Institute for Health and Welfare, Helsinki, Finland, and colleagues reported on the results of the FINGER Study – the first randomized controlled trial showing that it is possible to prevent cognitive decline using a multi-domain lifestyle intervention among older at-risk individuals. The results highlighted the value of addressing multiple dementia risk factors as a strategy to protect brain health. The FINGER model is now being replicated in the United States, Europe, Singapore, and Australia – including people from a variety of geographical and cultural backgrounds.

“We now can effectively prevent and treat heart disease with a combination of drugs and lifestyle. The same is true with some cancers; the same with HIV/AIDS. The same may also be true for Alzheimer’s disease and other dementias in the not too distant future,” said Maria C. Carrillo, PhD, Alzheimer’s Association Chief Science Officer.

“We must test all options to treat and prevent this horrible disease. We must find the answers for the millions dying with Alzheimer’s and their families, and the tens of millions more who will become affected if we do not act now. The Alzheimer’s Association is extremely proud to launch this clinical trial with our scientific partners,” Carrillo said.

Also announced today at AAIC 2017:

  • Interim results of the IDEAS Study, which is testing the impact on medical management of brain PET scans to detect amyloid protein. Amyloid forms the hallmark brain plaques of Alzheimer’s disease.
  • A possible blood marker for amyloid build up in the brain.
  • New insights into how amyloid and tau proteins spread through the brains of people with Alzheimer’s. Abnormal tau forms brain tangles – the other hallmark lesion of Alzheimer’s.

U.S. study to PrOtect through a lifestyle INTErvention to Reduce risk (US POINTER)
Increasing age is the greatest risk factor for Alzheimer’s disease. With the aging of the global population – and the slow progress of developing and testing drug treatments – prevention is pivotal in managing the inexorable rise in global cases of Alzheimer’s and other dementias.

In 2014, a large-scale two-year study in Finland in healthy older adults at increased risk of cognitive decline and dementia (the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability, or FINGER Study) found that a two-year combination therapy involving physical exercise, nutrition, cognitive stimulation, and self-monitoring of heart health risk factors had a protective effect on cognitive function. These results were first reported at AAIC 2014 in Copenhagen.

According to Co-Principal Investigator Laura Baker, PhD, of the Wake Forest School of Medicine, Winston- Salem, North Carolina, the U.S. study to PrOtect through a lifestyle INTErvention to Reduce risk (US POINTER) is modeled on the FINGER study. It will test whether two years of a combined intervention that includes physical exercise, nutritional counseling and modification, cognitive and social stimulation, and improved self- management of medical co-morbidities benefits cognitive function in older adults at increased risk of cognitive decline and dementia. The comparison group will receive health education and support through in-person group meetings on health- and aging-related topics, and annual feedback on laboratory tests.

Starting in 2018, 2,500 study participants 60-79 years old will be identified using a medical record search to select those with medical conditions that have been linked to an increased risk for dementia (e.g., hypertension and other cardiovascular events, elevated blood sugar). Information about family history of Alzheimer’s, physical activity level, and current cognitive status and mood will be collected in follow-up interviews to further identify eligible participants. Local Alzheimer’s Association offices nationwide will participate in intervention delivery. National partnerships will be developed with community-based organizations to deliver the exercise, nutrition, social and medical aspects of the intervention.

The success of the intervention will be evaluated based on two-year change in a global measure of cognitive function focused on short-term memory, attention and concentration.

“As of now, there are no approved medications that have produced results similar to the FINGER Study. There is a pressing need to test the effectiveness of a multicomponent lifestyle intervention in larger and more diverse populations, such as the United States,” said Baker. “The lifestyle intervention in US POINTER is an important multi-dimensional strategy to protect brain health and potentially reduce risk of dementia.”

An update on FINGER and overviews of the Singapore (SINGER) and Australia (Maintain Your Brain) prevention studies will also be reported at AAIC 2017. The worldwide effort, collectively referred to as WW- FINGERS, supports a collaborative network of trials and experienced investigators to facilitate harmonization of research methods, and sharing of experiences and data for maximum global scientific impact.

Clinical Impact of Brain Amyloid PET Scans – Interim Results from the IDEAS Study
Launched in 2016, the four-year Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) study is evaluating the impact of brain amyloid PET scans on patient management and health outcomes. Participants are more than 18,000 Medicare beneficiaries age 65+ with mild cognitive impairment (MCI) or atypical dementia who meet published Appropriate Use Criteria (AUC) for clinical amyloid PET. Before brain amyloid PET scans – which detect amyloid plaques, a core feature of Alzheimer’s – amyloid plaques could be seen only during autopsies, making it much harder to give living patients a definitive diagnosis.

At AAIC 2017, Principal Investigator Gil Rabinovici, MD, of the Memory and Aging Center, University of California, San Francisco, and colleagues reported early results from IDEAS assessing changes in patient management in the first 3,979 participants for whom case report forms were completed by participating dementia specialists both before and 90 days after the PET scans.

The pre-PET form documented the specialist’s management plan assuming no access to amyloid PET; the post- PET form recorded the medical management plan approximately 90 days after receiving results from a brain amyloid PET with an FDA-approved beta-amyloid imaging agent.

The researchers measured the rate of change between pre- and post-PET medical management, including one or more of: Alzheimer’s disease drug therapy, other drug therapy, and counseling about safety and future planning. Participants’ median age was 75 (range: 65-95); 64.4% were diagnosed with MCI, 35.6% met criteria for dementia. The most common suspected cause of cognitive impairment prior to PET was Alzheimer’s disease (76.3%). Rates of amyloid PET positivity were 54.3% in MCI and 70.5% in dementia.

Changes in medical management were seen in 67.8% of MCI patients (47.8% change in AD drugs, 36.0% change in other drugs, 23.9% changes in counseling), and in 65.9% of dementia patients (47.7% change in AD drugs, 32.2% change in other drugs, 15.3% change in counseling). Amyloid PET scans also reduced the need for additional diagnostic testing such as neuropsychological testing (from 26.3% recommended pre-PET to 11.0% recommended post-PET) and spinal fluid testing (from 10.5% to 1.0%).

“Our original hypothesis was that having amyloid PET scan results would change medical management in 30 percent of cases,” Rabinovici said. “Our interim results suggest we are well on track to see an effect of at least that magnitude, and perhaps greater, when the final results are available.”

“We look forward to reporting the results from the full study population. We are very grateful to the Centers for Medicare & Medicaid Services for their support of the IDEAS Study as our results indicate that access to this technology is making a real difference in the care of patients,” Rabinovici added.

The IDEAS Study is led by the Alzheimer’s Association and managed by the American College of Radiology.

The IDEAS Study was developed in response to CMS’ 2013 National Coverage Decision (NCD) on amyloid PET imaging in dementia and neurodegenerative disease (CAG-00431N) not to cover the scans because “the evidence is insufficient to conclude that the use of positron emission tomography (PET) amyloid-beta (A?) imaging is reasonable and necessary for the diagnosis or treatment of illness or injury or to improve the functioning of … Medicare beneficiaries with dementia or neurodegenerative disease.” Under the NCD, Medicare will provide coverage for one amyloid PET scan per patient enrolled in an approved clinical study.

A working group convened by the Alzheimer’s Association and the Society of Nuclear Medicine and Molecular Imaging (SNMMI) developed AUC for brain amyloid PET scans. The AUC indicate that amyloid PET should only be considered in patients with clear, measurable cognitive deficits when there is substantial diagnostic uncertainty after a comprehensive evaluation by a dementia specialist. According to AUC, amyloid PET may have greatest value in patients with either: (1) progressive, unexplained mild cognitive impairment (MCI); or (2) dementia of uncertain cause due to atypical or mixed symptoms, or unusually early age-of-onset.

A Blood Biomarker for Amyloid Plaques?
There is substantial evidence implicating amyloid-beta in the cause and/or progression of Alzheimer’s disease. Currently, a spinal tap or PET scan can detect deposition of amyloid in the brain, which precedes and increases the risk of progression to Alzheimer’s disease dementia. However, due to the invasiveness of a spinal tap and the radioactivity, limited availability and cost of PET scans, there is an urgent need for a simpler, more practical test for amyloid deposition, such as a blood test.

In order to investigate a blood-based amyloid biomarker, Randall Bateman, MD, and scientists at Washington University School of Medicine in St. Louis adapted their previously reported Stable Isotope Label Kinetics (SILK) method to measure amyloid in the blood – how fast it is created and how fast it is cleared away.

Participants were 41 older adults either with or without amyloidosis in the brain; they had either clinically diagnosed late-onset Alzheimer’s or were cognitively normal age-matched controls. All participants had brain PET amyloid imaging and/or cerebrospinal fluid (CSF) amyloid measures to detect brain amyloidosis. Blood sampling was conducted over 24 hours, and analyzed in a blinded fashion so researchers didn’t know which samples were from amyloid positive or amyloid negative people.

The scientists found the longer, stickier form of amyloid (known as A?42) was created and removed significantly faster in amyloid positive participants compared to amyloid negative participants. The findings were similar to prior studies done in CSF, suggesting that the amyloid levels detected in blood can accurately reflect the amyloid buildup in the brain. Additional results of a larger validation study will also be reported at AAIC 2017.

“These findings are important because they support the idea that blood amyloid interacts with and is derived from the brain,” Bateman said. “We’re excited because the results also suggest that blood-derived amyloid-beta may be useful as a rapid and inexpensive screening test for brain amyloidosis, and may be able to identify people who are at higher risk of Alzheimer’s disease very early in the process.”

“Having a simple and inexpensive blood test for screening is likely to greatly accelerate clinical trials to find Alzheimer’s drugs. And, it could facilitate widespread treatment when effective anti-amyloid therapeutics are developed,” Bateman added. “We envision that one day soon, as part of a regular screening for cholesterol and blood pressure, a person may also get a blood test to find out if the amyloid protein is building up in the brain, and then go on specific treatments to prevent the onset of Alzheimer’s disease dementia. This would be similar to the already successful approach of screening for and treating high cholesterol to reduce the risk of heart attacks and strokes.”

This research was supported by an Alzheimer’s Association Zenith award grant and an NIH R01 study.

Amyloid and Tau Spreading Pathways in the Brain, Correlated with Genetics
The ability to employ advanced imaging technology to “see” both of the hallmark proteins of Alzheimer’s (amyloid and tau) in the living brain is a significant recent advance in the field. It may prove to be transformational not only in our understanding of the disease and its progression but also in its potential to accelerate drug discovery.

According to Jorge Sepulcre, MD, PhD, of Massachusetts General Hospital and Harvard Medical School, Boston, understanding the “spreading” phenomenon of abnormal tau and amyloid-beta proteins in the brain is critical to knowing what is causing the devastating cell damage and relentless symptoms of people with Alzheimer’s.

Sepulcre and colleagues developed a novel imaging approach to investigate the spreading pathways of tau and amyloid deposits over time, as well as their genetic vulnerabilities, in a longitudinal sample of elderly participants in the Harvard Aging Brain Study. Eighty-eight (88) study participants, average age about 76, were divided into two independent samples: (1) a cross-sectional sample of 69 people; and (2) a 1-2 year follow-up longitudinal sample of 19 subjects.

The researchers found that tau and amyloid appear to accumulate along distinctive pathways in the brain; the same communication pathways, or neural networks, we use for daily brain function. According to their findings, tau – which we know starts in the middle of the brain memory center – spreads forward and out toward the front of the brain. Amyloid, which starts in the back of the brain, spreads further back and outward from the middle. Specifically:

  • Medial/inferior temporal lobe areas project pathways of Tau-spreading toward anterior pole, lateral and posteriomedial temporal cortex, and orbitofrontal cortex.
  • Posterior cingulate cortex spreads A? toward surrounding areas and lateral parietal lobe.

The scientists discovered that 354 genes were significantly associated with the tau spreading pathway, including the MAPT gene, which was previously associated with Alzheimer’s disease risk. They also found 216 genes, including the CLU gene, significantly associated with the amyloid pathway. Additional analysis characterized the tau spreading genetic profile as “axon-related” and the amyloid-spreading genetic profile as “dendrite-related”. APOE, the gene with the highest impact on Alzheimer’s risk, was found to be the most central gene linking tau- and amyloid-spreading pathways.

“Our results reported at AAIC 2017 suggest that tau and amyloid advance through different brain systems over time,” Sepulcre said. “We also discovered certain genetic traits that may confer tau or amyloid vulnerability in the brain.”

“The findings may improve our ability to track responses to potential therapeutic interventions in the future,” Sepulcre added. “In addition, when more effective drug therapies become available, these results may help doctors determine which patients should get which therapies, and the optimum time to take them.”

The Alzheimer’s Association International Conference (AAIC) is the world’s largest gathering of researchers from around the world focused on Alzheimer’s and other dementias. As a part of the Alzheimer’s Association’s research program, AAIC serves as a catalyst for generating new knowledge about dementia and fostering a vital, collegial research community.
AAIC 2017 home page: www.alz.org/aaic/
AAIC 2017 newsroom: www.alz.org/aaic/pressroom.asp

About the Alzheimer’s Association®
The Alzheimer’s Association is the leading voluntary health organization in Alzheimer’s care, support and research. Our mission is to eliminate Alzheimer’s disease through the advancement of research, provide and enhance care and support for all affected and reduce the risk of dementia through the promotion of brain health. Our vision is a world without Alzheimer’s. Visit alz.org or call +1 800.272.3900.

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  • Laura D. Baker, PhD, et al. U.S. Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (US- FINGER). (Funder: Alzheimer’s Association)
  • Gil D Rabinovici, MD, et al. Impact of Amyloid PET on Patient Management: Early Results from the IDEAS Study. (Funder(s): U.S. Center for Medicare and Medicaid Services, Alzheimer’s Association, Eli Lilly, GE Healthcare, Piramal)
  • Randall J Bateman, MD, et al. Concentrations and Stable Isotope Label Kinetics of Human Plasma Amyloid Beta. (Funder(s): U.S. National Institutes of Health, Alzheimer’s Association)
  • Jorge Sepulcre, MD, PhD, et al. In Vivo spreading Pathways of Tau and Amyloid Accumulation and Its Genetic Underpinnings. (Funder(s): U.S. National Institutes of Health, Alzheimer’s Association)

What happened at AAIC 2017? Be the first to know – Alzheimer’s – Optimum Senior Care – Chicago In Home Caregivers

What happened at AAIC 2017? Be the first to know –  Alzheimer’s – Optimum Senior Care – Chicago In Home Caregiverswww.OptimumSeniorcare.com

The Alzheimer’s Association International Conference®2017 (AAIC®) has concluded, and we close this gathering of the field’s leading dementia science researchers with renewed determination to work together to end this disease.
We can – and must – build on this momentum. We all must continue to work together to help the Alzheimer’s Association address the global dementia crisis by providing education and support to the millions who face dementia every day, while advancing vital research toward methods of treatment, prevention and, ultimately, a cure.
Your support today is a symbol of your commitment to continue exploring the important findings announced at this conference, including:

  • Brain amyloid PET scans may substantially impact medical management of people with dementia, according to interim results from the Imaging Dementia – Evidence for Amyloid Scanning (IDEAS) Study, which is led by the Alzheimer’s Association and managed by the American College of Radiology. This data will be submitted to Medicare as supportive evidence for why scans should be covered by Medicare in the future.
  • A small but intriguing new study investigated using a blood test for amyloid – a substance that accumulates in the brains of people with Alzheimer’s. Blood tests are simpler than spinal taps and less expensive than PET scans – which is how we currently measure amyloid.
  • More than one-third of global dementia cases may be preventable through addressing lifestyle factors, according to The Lancet Commission on Dementia Prevention, Intervention and Care.

Please know that your support makes advances like these possible and provides ongoing care and support for those affected by this devastating disease. For a recap of the highlights from AAIC, read the latest ?updates or watch these videos.
The world’s foremost Alzheimer’s investigators, clinicians and care providers have returned to their important work. Now we must return to ours. Now more than ever, we rely on your support to move forward in this fight.
As we work to change the trajectory of Alzheimer’s disease, we must continue to fight this disease on every front. Thank you for your gift to advance research while providing care and support every day to those affected by Alzheimer’s.

Volunteer Spotlight: Drew Malone – Alzheimer’s – Optimum Senior Care – Chicago In Home Caregivers

Volunteer Spotlight: Drew Malone – Alzheimer’s – Optimum Senior Care – Chicago In Home Caregiverswww.OptimumSeniorCare.com

The Alzheimer’s Association® counts on 35,000 passionate volunteers nationwide to inspire and make a difference in the fight against Alzheimer’s disease. Volunteers show their passion for the cause by dedicating their time and talents. Illinois Chapter volunteer, Drew Malone shares his story about how volunteering for the organization has become an important part of his life.

The Alzheimer’s Association® counts on 35,000 passionate volunteers nationwide to inspire and make a difference in the fight against Alzheimer’s disease. Volunteers show their passion for the cause by dedicating their time and talents. Illinois Chapter volunteer, Drew Malone shares his story about how volunteering for the organization has become an important part of his life.

What is your personal experience with Alzheimer’s?
My grandfather started showing strong signs of Alzheimer’s disease back in 2011. He would call twice to confirm the time for dinner the day we all went out. As he started to slip, I became more aware on a personal level of how the disease not only affects him but also our entire family. We are still caring for my grandfather to this day. Alzheimer’s is very unique for being number six in the top 10 leading causes of death in the U.S. Unlike heart disease, lung cancer and diabetes, Alzheimer’s has little to no voice from those who are diagnosed. Currently there is no cure and there are no survivors. It is up to the families of those who are affected to raise awareness and become advocates.

What kind of volunteer work do you do for the Association?
I have been a Junior Board member for the past two years, and have participated in the Alzheimer’s Chicago Walk to End Alzheimer’s® the past three years. I’ve also been a volunteer for Bankers Life Forget Me Not Days® the past two years, and was on the planning committee for this year’s Paint the Night Purple event which raised a record level of funds.

Why do you think others should volunteer with the Alzheimer’s Association?
It is the only disease in the nation’s top 10 leading causes of death with no treatment, no prevention and no cure. Until there is a substantial treatment, it is only going to affect us all more every day. It’s important for people to know how much Alzheimer’s disease is going to cost them and educate them on how to prepare for it.

Volunteer Today!
Read more volunteer stories or view various ways you can become involved. The work of volunteers is critical to achieving our vision of a world without Alzheimer’s disease.